摘要
目的 :比较腹腔化疗和静脉化疗对胃肠道癌术后患者免疫功能的影响。方法 :40例胃肠道癌患者随机分为两组 ,每组 2 0例 ,一组接受腹腔化疗 ,另一组接受静脉化疗 ,检测化疗前后患者血清中 T细胞亚群和 s IL- 2 R水平。结果 :化疗后血清 CD3、CD4和 s IL- 2 R水平较化疗前明显下降 ,两组间 CD3、CD4、CD8变化无显著差异 ,腹腔化疗组化疗后血清 s IL - 2 R水平显著低于静脉化疗组。结论 :腹腔化疗比静脉化疗对机体免疫的影响小 ,提倡腹腔化疗。
Objective:To compare the effect of postoperative intraperitoneal chemotherapy (PIC) on the immunity of gastrointestinal carcinoma (GC) patients with that of intravenous chemotherapy (IVC). Methods:40 patients were divided into two groups,one group received PIC and the other received IVC. The serum T lymphocyte subsets (T LS) and sIL 2R level before and after the chemotherapy were determined.Results:Serum CD 3,CD 4 and sIL 2R in GC patients were significantly decreased after the chemotherapy,however serum CD 3,CD 4,CD 8 levels were similar between PIC and IVC.Mean sIL 2R level in PIC group was lower than that in IVC.Conclusion:PIC affects the immunity more moderate than IVC dose and should be recommended as possible.
出处
《华夏医学》
2001年第4期413-414,共2页
Acta Medicinae Sinica
