摘要
目的了解进展期大肠癌术后早期腹腔灌洗化疗对防治腹腔内复发和肝脏转移的价值。方法选择１９９０年～１９９７年经手术及病理证实的１０２例侵及浆膜或腹腔癌胚抗原增高的大肠癌，随机分成腹腔灌洗化疗组５４例，静脉化疗组４８例。腹腔灌洗化疗组于手术当日开始用４３～４５℃的双蒸馏水１５００～２０００ｍｌ加５Ｆｕ１ｇ、ＭＭＣ１０ｍｇ行腹腔灌洗，连续应用６次；静脉化疗组用５Ｆｕ１ｇ、ＭＭＣ８ｍｇ每日静滴１次，连续６次；两组各用６次后改为口服呋喃氟脲嘧啶，总量为４０ｇ。结果静脉化疗组腹腔内复发１２例，肝脏转移６例；腹腔灌洗化疗组腹腔内复发２例，肝脏转移２例。两组未见并发症。结论术后早期腹腔灌洗化疗对防治进展期大肠癌腹腔内复发和肝脏转移有明显疗效，而且方法简单，安全。
Objective To study the effect of early postoperative intraperitoneal perfusion chemotherapy (IPPC) on the prevention of peritoneal recurrence and liver metastasis in patients with advanced colorectal cancer. Methods From 1990 through 1997, 102 patients with advanced colorectal cancer were admitted. The tumor invaded the intestinal serosa with elevated CEA in the peritoneal fluid. Fifty four of the 102 patients, beginning from the operation day, were given IPPC, once per day for 6 days, with warm(43～45℃) sterile double distilled water containing 1 g 5 Fu and 10 mg MMC. The other 48 patients, as control, received 1 g 5 Fu and 8 mg MMC by iv infusion, once per day for 6 days. In addition, oral tegafur was given to all patients with a total dose of 40 g. Results In patients treated with IPPC, peritoneal recurrence developed in 2 patients, liver metastasis in 2 patients whereas 12 cases had peritoneal recurrence and 6 had liver metastasis in patients treated by iv infusion. No complication developed in any of the treated patients. Conclusion IPPC is effective in preventing tumor recurrence in the peritoneal cavity and metastasis to the liver in patients with advanced colorectal cancer. The treatment procedure is simple and safe.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1998年第3期222-224,共3页
Chinese Journal of Oncology
关键词
大肠肿瘤
手术后
腹腔灌洗
药物疗法
Colonic neoplasms/surgry Colonic neoplasms/drug therapy Rectal neoplasms/surgry Rectal neoplasms/ drug therapy Intraperitoneal chemotherapy
