摘要
对氨基苯酚在 TEBA相转移催化下 ,与氟里昂 -2 2进行醚化反应制得对二氟甲氧基苯胺 ( 2 ) ,2用乙酸酐乙酰化得对二氟甲氧基乙酰苯胺 ( 3) ,3经浓 H2 SO4 和浓 HNO3 混酸硝化得 N-( 2 -硝基 -4 -二氟甲氧基 )苯基乙酰胺 ( 4 ) ,最后在室温下直接以 Na OH水溶液将 4水解得标题化合物 1 ,总收率达到 30 % .研究了不同条件对醚化反应的影响 ,获得了合成
The reaction of the 4 aminophenol with freon 22 by phase transfer catalysis TEBA gave 4 difluoromethoxyphenylacetimide(2). Acetification of 2 gave N(4 difluoromethoxy) phenylacetimide(3) under acetic anhydride. Then, the N(4 difluoromethoxy)phenylacetimide (3) produced the N (2 nitro 4 difluoromethoxy)phenylacetimide(4) under the action of strong nitric acid and strong sulfuric acid. At last, the title compound was easily obtained only after its hydrolysis by adding the concentrated sodium hydroxide solution, and the overall yield was 30%. The effect of different conditions on the etherification was also studied, and the optimal technology for preparation of 2 was found.
出处
《徐州师范大学学报（自然科学版）》
CAS
2001年第4期53-55,共3页
Journal of Xuzhou Normal University(Natural Science Edition)
基金
江苏省科委新产品试制项目 ( HX980 7)
