摘要
利用改良寇氏法检测头孢曲松钠他唑巴坦钠 (3∶1和 5∶1)的抗菌活性 .结果表明 :头孢曲松钠他唑巴坦钠对产酶的金黄色葡萄球菌和埃希氏大肠杆菌感染的小鼠体内抗菌活性(ED50 )分别为 4 .0mg·kg- 1、4 .3mg·kg- 1和 0 .0 0 5 6mg·kg- 1、0 .0 0 6 8mg·kg- 1,头孢曲松钠舒巴坦钠 (2∶1)的ED50 值分别为 6 .6mg·kg- 1和 0 .0 1147mg·kg- 1,单组分头孢曲松钠的ED50 为 10 .3mg·kg- 1和 0 .0 6 4 9mg·kg- 1;头孢曲松钠他唑巴坦钠对绿脓杆菌感染的ED50 为 8.2mg·kg- 1和11.2mg·kg- 1,头孢曲松钠舒巴坦钠的ED50 为 16 .1mg·kg- 1,单组分头孢曲松钠的ED50 为 35 .4mg·kg- 1.提示 :头孢曲松钠他唑巴坦钠对产酶的金黄色葡萄球菌、埃希氏大肠杆菌和绿脓杆菌感染的小鼠有明显抗菌作用 。
The authors determined the antibacterial activity of ceftriaxone sodium and tazobactam sodium(3 to 1 and 5 to 1)in mice's body by using minor modified karbers's method.The results showed that in mice's body infected by zymogenic Staphylococcus aureus and Escherichia coli ,the ED 50 values of ceftriaxone sodium and tazobactam sodium(3 to 1 and 5 to 1) resisting these bacteria were 4.0 mg·kg -1 ,4.3 mg·kg -1 and 0.005 6 mg·kg -1 ,0.006 8 mg·kg -1 ,respectively;the ED 50 values of ceftriaxone sodium and sulbactam sodium(2 to 1) 6.6 mg·kg -1 and 0.011 47 mg·kg -1 ,respectively; and the ED 50 values of a single composed compound of ceftriaxone sodium 10.3 mg·kg -1 ,0.064 9 mg·kg -1 .Meanwhile,the results also showed that in mice's body infected by Pseudomonas aeruginosa, the ED 50 values of ceftriaxone sodium and tazobactam sodium resisting the bacteria were 8.2 mg·kg -1 and 11.2 mg·kg -1 ,respectively; the ED 50 value of ceftriaxone sodium and tazobactam sodium 16.1 mg·kg -1 ;and the ED 50 value of a single composed compound of ceftriaxone sodium 35.4 mg·kg -1 .Thus,a conclusion was drawn that ceftriaxone sodium and tazobactam sodium had an obviously antibacterial activity on the mice infected by zymogenic Staphylococcus aureus,Escherichia coli ,and Pseudomonas aeruginosa, and that it was obviously superior to the ceftriaxone sodium(single composed compound) and the ceftriaxone sodium and sulbactam sodium.
出处
《海南大学学报（自然科学版）》
CAS
2001年第4期370-372,共3页
Natural Science Journal of Hainan University
关键词
头孢曲松钠他唑巴坦钠
头孢曲松钠舒坦钠
抗菌作用
药理学
头孢菌素
ceftriaxone sodium and tazobactam sodium
ceftriaxone sodium and sulbactam sodium
antibacterial activity
in mice's body
