摘要
运用剧烈运动小鼠模型,研究了白首乌C21甾甙(总甙)抵抗内源性自由基氧化损伤的功能。对红细胞抗渗透性、肝脏中过氧化脂质含量和超氧化物歧化酶(SOD)活性、红细胞过氧化氢酶(CAT)活性以及血液谷胱甘肽过氧化物酶(GSH-Px)的活性等5项指标进行了实验研究。结果表明,剧烈过度的运动会导致红细胞的渗透性增加和肝脏中过氧化脂质含量的提高,并会引起SOD、CAT和GSH-Px三种体内抗氧化酶活性的降低;而白首乌总甙可抑制上述这种由剧烈过度运动所引发的氧化损伤。因而认为,总甙通过自身对氧自由基的直接清除作用和激活机体的抗氧化防御系统两个方面来提高机体的抗氧化水平,减少自由基对机体的危害,来起到延缓衰老和滋补保健的作用。
The function of Baishouwu C21 steroidal glycosides(general glycosides) in resisting oxidation damage caused by endogenous free radicals was studied with exeperimental model of violent exercise mice.Five experiments were carride out,including anti-osmosis of erythrocytes, the content of peroxidated lipids and the activity of superoxide dismutase(SOD)of the liver,the activity of catalase(CAT)of erythrocytes,and the activity of GSH-peroxidase(GSH-Px)of the blood.The results indicated that exhaustive exercise cause not only the increase of the osmosis of erythrocytes and the content of peroxidated lipids of the liver,but also the decrease of the activity of all the three inner anti-oxidation enzymes namely SOD,CAT and GSH-Px;and that general glycosides could restrain from such oxidative damage induced by exhaustive exercise.This suggested that by both of their direct scavenging capacity on oxygen free radicals and the activation of the anti-oxidation.immune system,general glycosides could enhance the anti-oxidation capability of the organ and reduce the damage of free radicals to the organ to chieve anti-ageing and health benefit effect.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2001年第12期22-25,共4页
Food Science
