摘要
目的:探讨细胞间粘附分子-1(ICAM-1)在胃癌中的表达及其临床意义。方法:采用免疫组织化学法检测胃癌组织中ICAM-1的表达情况,并与临床病理参数作相关分析。结果:58例胃癌组织中,ICAM-1的阳性表达率为34.5%,其表达率与肿瘤浸润深度、肝转移及血管侵犯无明显相关(P＞0.05);ICAM-1表达阳性率在肠型胃癌显著高于弥漫型胃癌(P＜0.01),淋巴结转移者显著低于无淋巴结转移者(P＜0.01);随肿瘤TNM分期的增高,ICAM-1的阳性表达率也逐渐下降(P＜0.05)。结论:胃癌组织中ICAM-1表达与淋巴结转移和肿瘤分期密切相关。
ve:To investigate the expression of intercellular adhesion molecule-1(ICAM-1) in gastriccarcinoma and to elucidate its clinical significance. Methods: ICAM-1 expression was studied in gas-tric carcinoma patients by means of the immunohistochemical assay. Results: In 58 cases of gastriccarcinoma, the positive expression rate of ICAM-1 was 34.5%. No correlation was observed betweenICAM-1 expression and the depth of tumor invasion, hepatic metastasis and vascular invasion(P>0.05).Its expression was higher in tumors without lymph node metastasis than those with positive lymph no-des, and higher in tumors of the intestinal-type than those of the diffuse-type(P＜0.01). A trend of de-creasing ICAM-1 expression was observed with the advancement of tumor staging. Conclusions: ICAM-1expression in gastric carcinoma is closely associated with lymph node metastasis and tumor staging.
出处
《外科理论与实践》
2001年第6期398-400,共3页
Journal of Surgery Concepts & Practice
基金
本课题受上海市医学发展基金资助(983008)
