摘要
应用肾上腺素(EPN)、二磷酸腺苷(ADP)和胶原(COLL)三种致聚剂,对52例糖尿病(DM)患者的血小板聚集功能进行测定,同时测定了血浆纤维蛋白原(Fg)浓度,并按有无血管并发症进行分组比较,并对血小板聚集功能与Fg,空腹血糖(FPG)、胆固醇(CH)和甘油三酯(TG)的关系进行了观察。结果表明,ADP诱导的各组血小板聚集功能(PAgT)均明显升高(P<0.001～0.05),有血管并发症组较无血管并发症组显著升高(P<0.05);但对EPN和COLL诱导的PAgT无显著性差异。血浆Fg浓度显著高于对照组(P<0.001),在无血管并发症的早期即显著高于对照组(P<0.001)。ADP-PAgT与FPG,CH和TG无相关关系,但与Fg浓度则呈明显的正相关(r=0.565,P<0.002)。提示PAgT和Fg与血管病变密切相关,可能为其发病因素之一。
Platelet aggregation induced by Epinephrine (EPN), adenosine diphosphate (ADP)
and collagen (COLL) in 52 patients with diabetes was studied. The concentration of
plasma fibrinogen (Fg) was measured at the same time. The relationship between
ADP-induced platelet aggregative test (ADP-PAgT)and Fg, fasting plasma glucose
(FPG), cholesterol (CH) and triglyceride (TG) was also observed. The patients fell
into two groups: one with vascular complications and the other without vascular
complications. The results showed that ADP-PAgT was significantly higher in both
of the patient groups than in the controls, and higher in the group with vascular
diseases than in the group without vascular diseases. No significant difference was
found in EPN-or COLL-induced PAgT. The concentration of plasma Fg in patients
with diabetes mellitus was higher than that in the controls. There was no correlation
between FPG, CH, TG and ADP-PAgF, but there was a positive correlation between
ADP-PAgT and Fg. (γ=0.565, P<0.002). The results indicated that the close
relation between PAgT and Fg may be one of the causes of vascular diseases in
diabetes.
出处
《青岛医学院学报》
1991年第3期230-233,共4页
Acta Academiae Medicinae Qingdao Universitatis
关键词
血小板
糖尿病
血管疾病
platelet aggregation
diabetes mellitus
vascular diseases
platelet function tests
fibrinogen
