摘要
目的 研究地塞米松对肢体缺血再灌注时白细胞介素 8(IL 8)和过氧化脂质 (LPO)的影响。方法 3 5例择期手术病人随机分为缺血再灌注组 (A组 )、地塞米松治疗组 (B组 )和非缺血对照组 (C组 )。以ELISA法和硫代巴比妥法分别测定IL 8和LPO的值。结果 A组病人IL 8在缺血再灌注后 2 0分钟显著升高 ;B组和C组则无显著变化。A组LPO在缺血再灌注后 10分钟、2 0分钟均显著升高 ;B组和C组均无显著变化。结论 肢体缺血再灌注可使IL 8和LPO显著增高。地塞米松对肢体缺血再灌注引起的IL
Objective To study the effects of dexamethasone on interleukin 8(IL 8) and lipid peroxides (LPO) during reperfusion after ischemia of the limb.Methods Thirty five adult patients were devided into three groups:ischemic reperfusion group(group A),dexamethasone treatment group(group B) and control group(group C).Blood IL 8 and LPO were measured before reperfusion,at 10,20 min after reperfusion.Results IL 8 was increased significantly at 20min after reperfusion compared with that before in group A,which was not changed markedly in group B and C.LPO was increased significantly at 10 and 20 min after reperfusion compared with that before in group A,which was not changed remarkably in group B and C.Conclusion Reperfusion injury after limb ischemia results in a marked increase in IL 8 and LPO,which can be depressed effectively by dexamethasone.
出处
《临床麻醉学杂志》
CAS
CSCD
2001年第7期372-373,共2页
Journal of Clinical Anesthesiology
