摘要
纳米粒子与生物体有着密切的关系 ,DNA/蛋白质复合体就在 15～ 2 0nm之间 ,多种病毒颗粒也是纳米级的超微粒子 .多肽抗原需要与适当载体形成复合物才能诱导有效的免疫应答 ,但载体效应难以避免 .纳米佐剂可以避免载体效应的发生 ,而且还是巨噬细胞 (Mφ)、树突状细胞 (DC)的首选吞噬目标 .纳米化的有机药物可提高其生物利用度、制剂的均匀性、分散性和吸收性 ;脂质体可使药物更快地到达靶向部位 ,而且特异性更强 .目前主要用理化的方法制作纳米材料 ,几乎所有的生化药品 ,特别是DNA药物的研究开发都可引入纳米材料 。
The loading of peptide into ultrafine host vesicles or in the nanometer size range is an important technique for the optimization of controlled peptide antigens delivery. There are closed relationship between the nanoparticle and the organism, the size range of DNA-protein complex is 15 similar to 20 nanometer. Several virus particles are also nanoparticle. For the nanoparticle adjuvants, the carrier effects and side effects and foreign body irritation will be avoid. Furthermore, the actual state of the nanoparticle materials is shown with 4 practical application examples, that is: a targeted cellular uptake by macrophage and dendritic cells; the strong immunity stimulation of nanocapsules, as new adjuvants, when loaded with viral or other antigens; the better blood-brain barrier transfer of a biochemistry drug when covalently bound to special liposomes; and the use of minivesicles for controlled site-specific anticancer drug release (tumor targeting). The nanoparticl materials were manufactured by physics and chemistry methods. Almost all biochemistry drug and DNA drugs, particularly, adjuvants for the epitope peptide vaccine were loaded with nanoparticle carriers for the good stability and body-friendly and biodegradable excipients.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2001年第6期832-835,共4页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金资助项目 (30 1 70 884)~~
