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肌肉介导的基因转移DNA药物及应用研究

Muscle-mediated gene transfer DNA medicine and its application
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摘要 介绍了肌肉介导的基因转移方法 ,探讨肌肉摄取DNA的机理、DNA药物的预防和治疗作用机制、DNA药物的具体应用以及影响DNA药物药效的因素 ,并讨论了DNA药物的安全性。
出处 《生物技术》 CAS CSCD 2001年第2期32-35,共4页 Biotechnology
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参考文献27

  • 1Wolff J A,Malone R W,Williams P,et al.Direct gene transfer into mouse muscle in vivo[J].Science,1990,247:1465-1468.
  • 2Hartikka J,Sawdey M,Jensen F C,et al.An improved plasmid DNA expression vector for direct injection into skeletal muscle[J].Human Gene Therapy,1996,7:1205-1209.
  • 3Donnelly J J,Friedman A,Martinez D,et al.Preclinical efficacy of a prototype DNA vaccineenhanced protection against antigenic drift in influenza-virus[J].Nat.Med.1995,1:583-587.
  • 4Woff J A,Dowty M E,Jiao S S,et al.Expression of naked plasmids by cultured myotubes and entry of plasmids into Ttubules and caveolae of mammalian skeletal muscle[J].J Cell Science,1992,103:1249-1252.
  • 5Hagstrome J E.Nonnuclera DNA binding proteins in striated muscle[J].Bioch.An.Mol.Med.1996,58:113-116.
  • 6Ulmer J B,Donnelly J B,Parker S,et al.Heterologous protection against influenza by injection of DNA encoding a viral protection[J].Science,,1993,259:1745-1748.
  • 7Wang Y,Xiang Z,Pasquini S,et al.The effect of passive immunization or maternally transferred immunity on the antibody response to a genetic vaccines to rabies virus[J].J Virol,,1998,72:1790-1796.
  • 8Porgador A,Irvine K R,Iwasaki A,et al.Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization[J].J Exp.Med,1998,188:1075-1082.
  • 9Kowalcayk D W,Ertl H C J.Immune responses to DNA vaccines[J].Cell.Mol.Life Sci,1999,55:751-770.
  • 10Martins L P,Lau L L,Asano M S,et al.DNA vaccination against persistent viral infection[J].J.Virol.1995,69:2574-2578.

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