摘要
目的 测定老年男性不同年龄组骨密度及有关的影响因素 ,以探讨老年男性骨质疏松的发生与有关影响因素的关系 ,为防治老年男性骨质疏松症提供理论依据。方法 双能量X线骨密度测定仪测定前臂骨密度 ;全自动生化分析法测定血清钙 (Ca)、磷 (P) ;放免法测定甲状旁腺素(PTH)、降钙素 (CT)、1,2 5 (OH) 2 D3、2 5 (OH)D3、白介素 6 (IL 6 )。 97例老年男性分为骨质疏松组与非骨质疏松组 ,并与 6 0岁以下男性进行比较。结果 老年男性骨密度、CT、1,2 5 (OH) 2 D3、2 5 (OH)D3 随年龄增长而降低 ,PTH、IL 6随着年龄增长而升高 (P <0 0 5 )。骨质疏松组与非骨质疏松组比较 ,PTH、IL 6二者明显升高 ,CT、2 5 (OH)D3、1,2 5 (OH) 2 D33者明显下降 (P <0 0 5～ 0 0 0 1)。结论 骨质疏松有关影响因素的改变使骨吸收增加 ,骨形成降低 ,导致骨丢失 。
Objective By measuring the bone mineral density and analyzing the factors related to osteoporosis in different age groups,to study the relationship between the both,and provide the theoretical basis of the prevention and treatment of osteoporosis in old men. Methods\ Forearm bone mineral density was measured by dual energy X ray absorptiometry (DEXA);serum calcium(Ca) and phosphorus(P)were measured with a full automatic biochemical analyzer;and serum parathormone (PTH).Calcitonin (CT),1,25(OH) 2D 3,25(OH)D 3 and interleukin 6(IL 6) were determined by radio immunoassay.Ninety seven old men,divided into osteoporosis group and non osteoporosis group,were compared with normal group of men under sixty years of age. Results\ Bone mineral density,CT,1,25(OH) 2D 3 and 25(OH)D 3 decreased,while serum PTH and IL 6 increased with aging.The formers in the osteoporosis group were also significantly lower than those in the non osteoporosis group( P <0 05).The latters in the osteoporosis group were also significantly higher than those in the non osteoporosis group( P <0 05～0 001), Conclusion\ The change of the above relative factors lead to increase in bone resorption and decrease in bone formation,causing bone loss and eventual osteoporosis.
出处
《中国骨质疏松杂志》
CAS
CSCD
2001年第3期221-223,共3页
Chinese Journal of Osteoporosis
关键词
骨质疏松
甲状旁腺素
降钙素
骨丢失
老年男性
骨吸收
Osteoporosis
Parathormone
Calcitonin
25 Hydroxy vitamin D 3 1,25 Dihydroxy vitamin D 3
Interleukin 6
