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脑源性神经营养因子与癫痫研究进展 被引量：4

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摘要 癫痫发作后 ,脑内BDNF的表达升高 ,其在时间和地域分布上有一定规律 ,这与其维持神经元存活和再生的功能紧密相关 ;BDNF对癫痫动物模型的痫性发作有阻止作用 ;痫性发作后 。
作者 段瑞生
机构地区 山东省千佛山医院保健科
出处 《国外医学（神经病学．神经外科学分册）》 2001年第4期266-268,共3页 Foreign Medical Sciences（Section On Neurology & Neurosurgery）
关键词 脑源性神经营养因子 癫痫 病理
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献15

  • 1Katoh - Semba R, Takeuchi IK, Inaguma Y, et al. Brain - derived neurotrophic factor, nerve growth and neurotrophin- 3 selected regions of the rat brain following kainic acid - induced seizure activity. Neurosci Res, 1999, 35(1): 19-29
  • 2Elmer E, KokaiaZ, KokaiaM, etal. Dynamic changes of brain-derived neurotrophic factor protein levels in the rat forebrain after single and recurring kindling- induced seizures. Neuroscience, 1998, 83(2):351 - 362
  • 3Schmidt - Kastner R, Humpel C, Wetmore C, et al. Cellular hybridization for BDNF, trkB, and NGF mRNAs and BDNF- immunoreactivity in rat forebrain after pilocarpine- induced status epilepticus. Exp Brain Res, 1996, 107(3): 331-347
  • 4Humpel C, Wetmore C, Olson L. Regulation of brain- deriyed neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol - induced epileptic seizures. Neuroscience, 1993, 53 (4): 909- 918
  • 5Mudo G, Jiang KH, Timmusk T, et al. Change in neurotropins and their receptor mRNAs in the rat forebrain after status epilepticus induced by pilocarpine. Epilepsia, 1996, 37(2): 198- 207
  • 6Garcia ML, Garcia VB, Isackson PJ, et al. Long- term alterations in growth factor mRNA expression following seizures. Neuroreport, 1997,8(6): 1445 - 1449
  • 7Tandon P, YangY, DasK, etal. Neuroprotective effects of brain-derived neurotrophic factor in seizures during development. Neuroscience,1999, 91(1): 293-303
  • 8Lanmet Y, ReibelS, CamahanJ, et al. Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat. Neuroreport, 1995, 6(14): 1937-1941
  • 9Osehobo P, dams B, Sazgar M, et al. Brain - derived neurotrophic factor infusion delays amygdala and perforant path kindling without affecting paired- pulse measures of neuronal inhibition in adult rats. Neuroscience, 1999, 92(4): 1367-1375
  • 10Rudge J S, Mather PE, Pasnikowski EM, et al. Endogenous BDNF protein is increased in adult rat hippocampus after a kainic acid induced excitotoxic insult but exogenous BDNF is not neuroprotective. Exp Neurol,1998, 149(2): 398-410

同被引文献48

  • 1夏薇,赵华,任爱华,沈维高.实验性抑郁症大鼠缰核和海马BDNF基因表达[J].中国免疫学杂志,2005,21(4):277-278. 被引量：15
  • 2易正辉,方贻儒,王祖承.抑郁症神经生化和神经电生理学研究进展[J].中国新药与临床杂志,2005,24(9):676-679. 被引量：24
  • 3Hyman CM, Hofer YA, Brade M, et al. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature, 1991, 350(3):230.
  • 4Ahmed ME, Richard JW. Tardive dyskinesia: Possible Involvement of Free Radicals and treatment with vitamin E. Schizophrenia Bulletin,1999, 25(4) :731.
  • 5Schooler NR, Kane JM. Research diagnoses for tardive dyskinesia. Arch Gen Psychiatry, 1982, 39(2) :486.
  • 6Durany NT, Michel RZ, Boissl KW, et al. Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr Res,2001, 52(1-2):79.
  • 7Eiji Shimizu, Kenji Hashimoto, Hiroyuki Watanabe, et al. Serum brainderived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls. Neuroscience Letters, 2003, 351(2): 111.
  • 8Guillin O J, Diaz P, Carroll N, Griffon, et al. BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization. Nature,2001, 411(1):86.
  • 9Altar CA, Whitehead RE, Chen R, et al. Effects of electroconvulsive seizures and antidepressant drugs on brain - derived neurotruphic factor protein in rat brain. Biol Psychiat, 2003, 54 (7) : 703 -709.
  • 10Shimizu E, Hashimoto K, Okamura N, et al. Alterations of serum levels of brain - derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiat, 2003, 54 ( 1 ) : 70 - 75.

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国外医学（神经病学．神经外科学分册）
2001年 第4期

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