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抑郁症神经生化和神经电生理学研究进展 被引量：24

Neurobiochemical and neuroelectrophysiologic studies of depression
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摘要 抑郁症的发病机制复杂,神经生化学理论是迄今最为“肯定”、并被临床药理“充分利用”的,用以阐述抑郁症发病的神经生物学机制,抑郁症的发生不但与去甲肾上腺素(NE)、5-羟色胺(5-HT)水平相关;也可能与多巴胺(DA)、乙酰胆碱(Ach)、神经肽、γ-氨基丁酸(GABA)能系统等多种神经递质及受体的功能紊乱有关,还与内分泌系统和神经营养因子系统等方面的异常有关。同时,抑郁症的发生还可能与神经认知功能的缺损及神经电生理学的改变有关。 The etiology of depression is complicated, which involves the neurobiochemistry, cognitive function impairment and neuroelectrophysiologic mechanism. The neurobiochemics mechamisms of depression, which are introduced to explain the neurobiological mechanism of depression through clinical psychopharmacology and hitherto have been presumed as the most trustworthy theory , involve neurotransmitters and receptors functional abnormalities of NE, 5-HT, DA, Ach, GABA and neuropeptide, together with endocrinium and neurotrophic factors .
作者 易正辉 方贻儒 王祖承
机构地区 上海市精神卫生中心
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2005年第9期676-679,共4页 Chinese Journal of New Drugs and Clinical Remedies
基金 国家自然科学基金资助项目(30270494) 国家科技攻关计划项目(2004BA720A21-020)
关键词 抑郁症 精神病理学 神经递质 神经生化 神经电生理学 depression psychopathology neurotransmitters neurobiochemistry neuroelectrophysiology
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献16

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二级参考文献28

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引证文献24

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中国新药与临床杂志
2005年 第9期

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