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胃癌CD_(44)V_6表达与胃癌生物学行为关系的研究

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摘要 目的 探讨胃癌CD_(44)V_6的表达与胃癌发生发展的关系,评价CD_(44)V_6在胃癌诊断、浸润转移以及预后的判断中的作用。方法 采用免疫组化方法(S-P法)检测10例正常胃粘膜上皮、101例异常增生的癌旁组织和胃癌原发灶中的表达情况,对胃癌标本进行系统的病理学检查。结果 CD_(44)V_6在正常胃粘膜呈阴性表达,在异常增生癌旁组织中呈弱阳性表达,胃癌组织阳性表达率为74%(75/101);胃癌CD_(44)V_6表达强度与胃癌浸润型生长、淋巴结转移、浸润深度密切相关(P<0.05),胃癌Ⅰ、Ⅱ期表达强度低于Ⅲ、Ⅳ期(P<0.05),而与其他临床病理因素无关。结论 CD_(44)V_6表达与胃癌发生发展密切相关,对胃癌组织进行CD_(44)V_6蛋白检测,有助于胃癌的早期诊断和预测胃癌进展程度,以及评估胃癌患者的预后。
出处 《实用肿瘤学杂志》 CAS 2001年第3期186-188,共3页 Practical Oncology Journal
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