摘要
目的 探讨老年肺心病胃运动功能与胃肠激素的关系。方法 用超声显像法检测30例老年肺心病患者使用西沙比利前后的胃运动功能 ,并测定血浆胃动素 (MTL)、生长抑素 (SS)、血管活性肠肽 (VIP)及脑啡肽 (ENK)的含量。结果 老年肺心病胃半排空时间明显延长 ,血浆MTL含量显著减少 ,SS、VIP及ENK异常增加 ;用西沙比利治疗后胃半排空时间明显缩短 ,血浆MTL水平明显升高 ,SS、VIP及ENK均明显降低。结论 胃肠激素紊乱是老年肺心病发生胃运动障碍重要原因之一 。
Objective To study the relationship between gastric motility and gastrointestinal hormones in aged cor pulmonale. Methods Parameters of gastric motility were measured before and after the treatment with cispride for four weeks by ultrasonography, and levels of Plasma MTL,SS,VIP and ENK were determined. Results As compared to controls gastric half emptying time of liquid was significantly delayed in patients with aged cor pulmonale and motility indices of gastric antrum were reduced;the levels of MTL were obviously decreased, the levels of SS,VIP and ENK were sharply increased; After the treatment with cispride, gastric half emptying time was significantly reduced and gastric motility indices were increased in aged cor pulmoale; levels of MTL were obviously increased and levels of SS、VIP and ENK were deeply decreased in aged cor pulmonale.Conclusion Imbalance of gastrointestinal hormones is one of major cause of gastrointestinal kinetic disorders in aged cor pulmonale; Cispride can obvious improve function of gastric motility in patients with aged cor pulmonale.
出处
《临床内科杂志》
CAS
北大核心
2001年第4期281-283,共3页
Journal of Clinical Internal Medicine
关键词
肺心病
胃运动
胃肠激素
西沙比利
老年人
Cor pulmonale
Gastric motility
Gastrointestinal hormones
Cispride
