摘要
目的 探讨改善胰腺缺血和钙通道阻断剂在急性重症胰腺炎治疗中的保护作用。方法 将 2 4例轻型急性胰腺炎患者随机分为对照组和治疗组。对照组采取常规保守治疗 ,治疗组重点改善胰腺缺血并使用钙拮抗剂。测定两组患者血液流变学变化及血液肿瘤坏死因子 (TNFα)、白介素 (IL 1β)、C 反应蛋白 (CRP)、血栓素 (TXB2 )及前列腺素 ( 6 酮 PGF1α)含量变化。结果 治疗组血液流变学异常得到明显改善 ,血TNFα、IL 1β、CRP、TXB2 和 6 酮 PGF1α含量均较对照组显著降低。结论 重点改善胰腺缺血和使用钙通道阻断剂在阻止急性胰腺炎重症化治疗中有明显保护作用。
Objective To investigate the pr ot ective effect of improving the pancreatic ischemia and calcium channel blockers on preventing the progression of acute pancreatitis. Methods Twenty-four patients with mild acute p ancreatitis were randomly divided into two groups: control group and treated g roup. Within the first 72 hours from the onset of AP, routine conservative manag ements were performed in control group, improving the pancreatic ischemia and pr eventing Ca^2+ overload were performed in treated group for two weeks. The hemorrheological parameters were measured at 1,4,7,14 days after adimission, sim ultanously, serum TNFα, IL-1β, C-reactive protein and plasma TXB_2, 6-keto -PGF_1α levels were determined with ELISA methods. Results The hemorrheological changes were impro ved in treated group, serum TNFα, IL-1β, C-reactive protein and plasma TXB_ 2, 6-keto-PGF_1_α levels were significantly decreased each time point in tr eated group as compared with control group. Conclusion Improving the pancreatic ischemia an d calcium channel blockers have protective effect through reducing the generatio n of cytokines and inflammatory mediators on preventing the progression of acute pancreatitis.
出处
《中国普外基础与临床杂志》
CAS
2001年第6期384-386,共3页
Chinese Journal of Bases and Clinics In General Surgery
关键词
急性胰腺炎
治疗
胰腺缺血
钙超载
细胞因子
Acute pancreatitis Treatment Pancreatic ischemia Calcium overload Cytokines
