摘要
目的 观察抗生素长、短程用药方法预防外科手术区感染的效果。 方法 全国 15家医院进行多中心前瞻性随机对照研究。 731例腹部外科手术患者被随机分为 2组 :围手术期短程用药组 (术后用药 1d)及长程用药组 (术后用药 3d)预防手术区感染。 2组患者在年龄、性别及手术种类等方面均无差异。预防用抗生素为奈替米星或合并使用甲硝唑。 结果 短程用药组感染率为0 84% (3 35 8) ,长程用药组感染率为 2 6 8% (10 373) ,2组差异无显著性意义 (P >0 0 5 )。 结论围手术期短程应用抗生素即可有效预防术后手术区感染 ,从药物经济学和合理用药的角度来说也优于长期用药。
Objective To evaluate the outcome of short- term antimicrobial prophylaxis versus long-term in surgical site infection( SSI). Methods 731 patients undergoing abdomina l operation from 15 hospitals were randomly divided into 2 groups. 358 patients were enrolled in the short-term group (24 h), and 373 patients in the long-ter m group (72 h). There was no difference between the 2 groups with regard to ag e, sex, and types of operation. Netilmicin was used alone or in combination with metronidazole. Results The rates of SSI in th e short-term and long-term groups were 084% and 268% ( P>005), re spectively. Conclusions The results demonstrat ed that the short-term antimicrobial agents prophylaxis is effective in the pre vention of post-operative SSI. The long-term one act does not better than the short-term in terms of rationality and pharmacoeconomics.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2001年第10期770-772,共3页
Chinese Journal of Surgery
关键词
手术区感染
抗生素
预防
腹部手术
Infection
Antibiotic prophyl axis
Treatment outcome
