摘要
目的 探讨复方丹参注射液与生脉注射液合用对阻塞性黄疸术后炎症介质及肾功能的影响。方法 将阻塞性黄疸与无黄疸的肝胆外科病人分成 3组 ,每组各 15例。黄疸对照组及无黄疸对照组术后给予一般治疗 ,复方丹参注射液加生脉注射液治疗阻塞性黄疸组术后 1～ 6天给予复方丹参注射液加生脉注射液 ,动态观察血浆内毒素 (L Ps)、肿瘤坏死因子 (TNF-α)、白细胞介素 - 6、8(IL - 6、IL - 8)、内皮素 (ET)以及转铁蛋白 (TFR)、尿白蛋白 (AL B)和尿视黄醇 (RBP)的变化。结果 复方丹参注射液加生脉注射液组术后 7天与术后 1天相比 ,L Ps、IL - 6、IL - 8、ET、TNF-α、TFR、RBP、AL B明显下降 (P<0 .0 1或 <0 .0 5 ) ,且低于或接近术前水平 ,其中 AL B、RBP与黄疸对照组术后 7天相比也有显著性差异 (P<0 .0 5 )。结论 复方丹参加生脉注射液对阻塞性黄疸病人术后血浆 L Ps有拮抗作用 ,同时降低其它炎症介质水平 。
Objective To investigate the effect of salvia miltiorrhiza and shengmai (SS) on inflammatory mediator and renal function in patients with obstructive jaundice (OJ). Methods This study included three groups: the OJ patients receiving SS for 6 days after operation (the SS group, n =15); the OJ patients not receiving SS (the OJ group, n =15); the patients with other hepato biliary disorders (the Non OJ group, n =15). The levels of ET, LPs, TNF α, IL 6, IL 8 and urine RBP, TFR, ALB were measured one day before operation and 1, 4, 7 days after operation. Results The SS group's LPs, TNF α, IL 6, IL 8, ET, RBP, TFR and ALB levels were obviously lower on Day 7 after operation as compared with those on Day 1 after operation ( P< 0.05). The urine RBP and ALB levels were significantly lower in the SS group than in the OJ group( P< 0.05). Conclusion The post operative use of salvia miltiorrhiza and shengmai for patients with obstructive jaundice may effectively decrease the postoperative levels of plasma LPs, ET, TNF α, IL 6 and IL 8. At the same time, salvia miltiorrhiza and shengmai may protect renal function by inhibiting inflammatory mediator and improving blood dynamics.
出处
《华西医科大学学报》
CAS
CSCD
北大核心
2001年第4期587-589,共3页
Journal of West China University of Medical Sciences
基金
卫生部科研基金资助 (项目编号 98-1-2 15 )
