摘要
目的 探讨阻塞性黄疸时炎症介质对肾脏功能的影响。方法 以 15例阻塞性黄疸患者 ( OJ组 )为研究对象 ,15例无黄疸的肝胆外科患者作为对照 ,动态观察 OJ患者减黄手术前后血内毒素 ( L PS)、肿瘤坏死因子 ( TNF-α)、内皮素 ( ET)、白细胞介素 - 6 ( IL - 6 )、白细胞介素 - 8( IL - 8)、尿白蛋白 ( UAL B)、尿视黄醇 ( U RBP)、尿转铁蛋白 ( U TFR)的变化。结果 OJ组手术前后炎症介质 L PS、TNF-α、ET、IL - 6、IL - 8浓度较对照组明显升高 ,同时AL B、RBP、TFR亦明显升高 ,且变化与炎症介质一致。结论
Objective To investigate the effect of inflammato ry transmitter on renal function in obstructive jaundice. Methords 15 patients with obstructive jaundice(OJ) as the experimental group and 15 non joundiced patients as the control group were involved in this study. The plasma ET, LPS, TNF α, IL 6, IL 8 and urine REP, TFR, ALB were measured in 15 patie nt s with OJ before and 1,4,7 days after surgery and in 15 patients without jaundic e as controls.Results The levels of plasma ET, LPS, TNF α, IL 6, IL 8 and urine RBP, TFR, ALB increased significantly at multiple time poin ts as compared with those in the non OJ patients ( P <0.05), and the changes o f plasma ET, LPS, TNF α, IL 6, IL 8 are the same as those of urine RBP, TFR, ALB. Conclusion These data suggest that there is interaction b et ween ET, LPS, TNF α, IL 6, IL 8 and the damage to renal function with OJ aft er surgery.
出处
《华西医科大学学报》
CAS
CSCD
北大核心
2001年第1期117-119,共3页
Journal of West China University of Medical Sciences
基金
卫生部科研基金资助
关键词
阻塞性黄疸
炎症介质
肾脏功能
手术后
Obstructive jaundice Inflammatory mediator Renal function
