摘要
目的 :探讨短期糖尿病雄性大鼠血糖、糖化血清蛋白、血清睾酮和性腺重量的动态变化。方法 :Wistar雄性大鼠分为正常对照组 (C)和糖尿病组 (D)。糖尿病组分别观察 1、3、5、7及 14d。动物处死后 ,称量各性腺重量 ,检测血糖、糖化血清蛋白和血清睾酮。结果 :糖尿病组血糖、糖化血清蛋白水平显著升高 ,血清睾酮于链脲菌素 (STZ)注射 3d后显著下降。糖尿病组附睾、精囊腺、前列腺重量显著降低 ;精囊腺、前列腺重量与血糖、糖化血清蛋白负相关 ,与血清睾酮正相关。结论 :短期糖尿病雄鼠睾丸附睾、精囊腺和前列腺发生明显变化 。
Objective:To study the effect of short term diabetes on the changes of sexual organ weights and serum levels of testosterone in male rats. Methods: All rats were divided into control (C) and diabetes (D). Diabetes group was observed on 1 day, 3 days, 5 days, 7 days, 14 days after injection of streptozotocin. All rats were killed for measurement of serum levels of glucose, glycosylprotein, testosterone and weights of sexual organs (testis, epididymis, seminal vesicle and prostate). Results: The serum levels of glucose, glycosylprotein of diabetes group decreased significantly,compared with those of control group; the serum levels of T lowered remarkably compared with control levels after three days of injection of STZ. The weight of epididymis, siminal vesicle and prostate reduced remarkably,compared with control group. The weights of siminal vesicle, prostate negatively correlated with serum levels of glucose and glycosyprotein, and they positively correlated with serum levels of testosterone. Conclusion: The sexual organs (testis, epididymis, seminal vesicle and prostate) of male rats with short term diabetes were damaged, and the changes of sexual organs closely related with the serum levels of testosterone besides irregular metabolism in diabetes.
出处
《白求恩医科大学学报》
CAS
CSCD
北大核心
2001年第5期486-489,共4页
Journal of Norman Bethune University of Medical Science
基金
国家自然科学基金资助项目 (39870 313)
