摘要
目的··:探讨5 -羟色胺选择性重摄取抑制剂 (SSRI)氟西汀和帕罗西汀对甲基苯丙胺 (MA)诱导的条件性位置偏爱效应(CPP)的影响。方法·· :采用倾向性实验程序。♂Wistar大鼠腹腔注射MA(0.5mg·kg-1)并训练8d ,d9测定大鼠对伴药盒的偏爱效应及测试前30min注射不同剂量 (2.5 -10.0mg·kg-1)氟西汀和帕罗西汀对该效应的影响。结果··:0.5mg·kg-1 的MA可以诱导大鼠对伴药盒产生显著的条件性位置偏爱 ;测试前注射氟西汀和帕罗西汀均可剂量依赖性地降低MA诱导的条件性位置偏爱效应的表达。结论··:氟西汀和帕罗西汀对MA的强化效应有抑制作用 。
Objective: To study the effect of serotonin selective reuptake inhibitors (SSRI) fluoxetine and paroxetine on the methamphetamine (MA)-induced conditioned place preference (CPP) in rats. Method: A biased procedure was adopted in the present study. Male Wistar rats were given MA (0.5 mg·kg-1,ip)and trained for 8 days. The preference for the drug-paired box of the rats and the effect of different doses of fluoxetine or paroxetine (ip) pretreatment before test on the CPP response were determined on the 9th day. Result: MA 0.5 mg·kg-1 appeared to be enough for rats to obtain a significant place preference for the drug-paired box. Pretreatment with 2.5,5.0 and 10.0 mg·kg-1 of fluoxetine and paroxetine before test inhibited the expression of this response in a dose-dependent manner. Conclusion: Fluoxetine and paroxetine inhibited the reinforcement effect of MA, indicating that this kind of drug might be potentially useful in the treatment of methamphetamine psychological dependence.
出处
《中国药物依赖性杂志》
CAS
CSCD
2001年第3期173-175,共3页
Chinese Journal of Drug Dependence
