摘要
目的 :比较氨氯地平和比索洛尔降压疗效、谷峰比值 (T/P)及对微循环的影响。方法 :6 0例原发性高血压 (EH)病人随机分为 2组 ,各 30例 ,分别给予氨氯地平和比索洛尔治疗 ,均为 5mg ,po ,qd×6wk。结果 :2组的降压总有效率分别是 93%和 90%。 2组降压幅度比较 ,P >0 .0 5。 2组间动态血压下降幅度比较 ,氨氯地平降低 2 4h ,舒张压幅度较比索洛尔大 ,P <0 .0 1。而 2 4h收缩压无显著性差异 ,P >0 .0 5。降压T/P比值均大于 50 % ,氨氯地平组和比索洛尔组均可改善甲皱微循环 ,但氨氯地平较比索洛尔改善更明显 ,P <0 .0 1。结论 :2药的降压疗效相似。但氨氯地平降压T/P比值较比索洛尔大。
AIM:To evaluate the efficacy and T/P ratio and microcirculation of amlodipine and bisoprolol in essential hypertension. METHODS: Sixty patients with mild to moderate essential hypertension (EH) were radomly divided into two groups and treated with amlodipine and bisoprolol 5 mg, po ,qd for 6 wk,respectively. RESULTS:The total effective rate of amlodipine group and bisoprolol group was 93 % and 90 %.After a 6 wk treatment,compared with each other,the reduction degrees of each group in SBP,DBP and 24 h SBP were similar ( P >0.05).Heart rate (HR) was decreased in bisoprolol group, but kept unchanged in the amlodipine group.The result of T/P ratio value of each group was all more than 50 %.T/P ratio in the amlodipine group was larger than that in the bisoprolol group. The results of detection of nailfold microcirculation showed that the microcirculation in the amlodipine group and the bisoprolol group had all been improved after treatment,and that in amlodipine group had been changed more . CONCLUSION:The two drugs have same potency in hypertensive monotherapy.T/P ratio of amlodipine is larger than that of bisoprolol.Amolodipine and bisoprolol can all improve the naifold microcirculation.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2001年第4期293-296,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
氨氯地平
高血压
微循环
降压效果
谷峰比值
比索洛尔
amlodipine
hypertension
ambulatory blood pressure monitoring
microcirculation [
