摘要
大量的流行病学资料和实验研究表明 ,长期服用NSAIDs可以预防大肠肿瘤的发生 ,其机制可能与NSAIDs抑制Cox 2合成PG有关 ,另外促进凋亡和抗氧化等也是NSAIDs作用机制之一 ,无胃肠道副作用的新的选择性Cox 2抑制剂有可能成为大肠肿瘤的化学预防剂。
Many epidemiological data and study of experiment show that adminstration of NSAIDs in long term can prevent the carcinogenesis of colorectal cancer, its mecanism can be associated with the inhibition of PG which is produced by Cox 2 way, in addition, promoting apoptosis and anti oxidation were also one of the mecanisms of NSAIDs, the new selective Cox 2 inhibitor without gastrointestinal side effect would become the chemopreventive drugs of colorectal tumor.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2001年第5期499-502,共4页
Chinese Pharmacological Bulletin
