摘要
目的 :探讨TRH对急性颅脑损伤后早期脑血流的影响。方法 :采用自由落体打击法致伤家兔 ,致伤力80 0× 80g·cm。 2 2只家兔随机分 2组。TRH治疗组 ,n =10 ,伤后 0 .5h开始静脉注射TRH ,此后每 0 .5h注射 1次 ,至伤后 4h。对照组n =12 ,按上述方法给予等量生理盐水。测量颅内压 (ICP)、脑组织含水量 ,应用经颅多谱勒超声 (TCD)测量舒张期末血流速度 (Vd)和脉动指数 (PI)。结果 :伤后 3h ,TRH治疗组Vd值显著增加 ,PI值降低 (P <0 .0 1) ;给药后ICP递增速度明显减慢 ,伤后 1.5h ,ICP显著低于对照组 (P <0 .0 1) ;脑组织含水量明显低于对照组(P <0 .0 1)。结论 :TRH能够显著增加颅脑损伤后的脑血流量 ,改善脑血流 ,降低ICP 。
Aim: To discuss the effect of TRH on the cerebral blood flow during the early phase after the experimental brain injury. Methods :Rabbits heads were hit with free falling object,the hitting energy being 800×80 g·cm.A total of 22 rabbits were randomized into 2 groups:TRH group,10 animals in which,TRH was injected intravenousg 0.5 h after injury, and every 0.5 h it was repeated at the dosage of 1.0 mg/(ml·kg), until 4 h after the injury;control group,12 animals weretreated the same way as described above but nor mal saline was used instead. V d, PI, ICP and the water content of brain constitution were measured with TCD, ICP monitor. Results :①Within 3 h after the injury, the Vd value of TRH group was markedly higher than that of the control group( P< 0.01).②After TRH was applied in the TRH group the increasing rate of ICP decreased, and 1.5 h after the injury the ICP was much lower than that of the control group. This was still the case 2.5 h after the medication till to the end( P< 0.01). ③The water content of brain tissue was much lower than that of the control group( P< 0.01). Conclusion :TRH can increase the velocity of CBF, improve brain blood flow, lower ICP and reduce brain edema as well, thus partially reverse the secondary damage due to brain ischemia.
出处
《河南医科大学学报》
北大核心
2001年第6期687-689,共3页
Journal of Henan Medical University
