摘要
探讨消炎痛对家兔急性脑外伤后早期脑血流速度的影响，评价消炎痛在脑外伤治疗中对颅内压 的作用。方法：采用自由落体打击法建立家兔急性颅脑损伤模型，并于致伤后 １０ｍｉｎ开始经静脉推注消炎痛４ ｍｇ·ｋｇ－１。应用经颅多谱勒超声，监测其对大脑中动脉血流速度的影响；同时用颅内压监护仪观察其对脑外伤后颅 内压的影响。结果：消炎痛可使脑外伤后心缩期脑血流速度显著降低（Ｐ＜０．０１），而对舒张末期脑血流速度影响 不大（Ｐ＞０．０５）。随着脑血流速度的降低，颅内压升高的速度及幅度也显著低于对照组（Ｐ＜０．０１）。结论：消炎痛 可在不影响正常脑循环的基础上，降低脑血流速度，减少脑血流量，防止脑血流过度灌注，从而有效地控制颅内压 的过度升高。
Aim:To investigate the early influence of indomethacin(IM)on cerebral blood flow velocity(CBV) after acute experimental brain iniury,and to evaluate the effects of IM on acute brain injury.Methods:The rabbit model with a number of features of clossed brain injury was established with direct hit.On the basis of this model,IM was injected through the vein(4mg/kg) 10 minites after brain injury,the effects of IM inbrain in jury were observed by the combination of CBV of middle cerebaal artery(MCA)with transcranial Dopple(TCD)and intracranial pressure(ICP)monitoring.Results:IM could singnificantly decrease the systolic velocity of MCA,whereas the diastolic velocity remained at a relatively stable status.At the same time,the speed and range of ICPrising in brain-injured animals were significantly lower than those in the control animals.Conclusion:IM could effectively control ICP rising after brain injury through its influence on CBV,nevertheless,it might not influence the cerebral blood supply.
出处
《河南医科大学学报》
1999年第2期71-73,共3页
Journal of Henan Medical University
关键词
脑外伤
消炎痛
经颅多谱勒超声
颅内压
兔
transcranial Doppler
brain injury
indomethacin
intracranial pressure
rabbit
