摘要
探讨复方抗瘤冲剂对小鼠肉瘤 180的作用及机制。通过体内实验 ,观察复方抗瘤冲剂对小鼠肉瘤180的抑瘤作用和免疫组化法检测p5 3和增殖细胞核抗原 (PCNA)的表达水平。结果显示 ,经复方抗瘤冲剂及其不同组合和CTX治疗 10天后 ,对小鼠肉瘤 180有不同程度的抑制作用 ,抑瘤率分别为 2 0 31%、6 5 6 %、12 5 %、19 0 6 %和 30 3%。同时各组药物对p5 3和PCNA的表达水平也有不同程度的影响。提示复方抗瘤冲剂对小鼠肉瘤 180的生长具有一定的抑制作用 ,其机制可能与抑制突变型p5
To study the anti tumor effect of 'Compound' granules on mice bearing sarcoma 180 and its possible mechanism, We observed the effect of 'Compound' granules on tumor weight and expression of p53 and PCNA in mice bearing sarcoma 180 by means of immunohisto chemistry. After treatment with 'Compound' anti tumor granules, anti tumor granules (Ⅰ,Ⅱ,Ⅲ) and CTX, the results showed that 'Compound' granules and the other four drugs could inhibit sarcoma 180 growth to various extent, and the rates of inhibition were 20 31%, 6 56%, 15 0%, 19 06% and 30 3%, respectively. Meanwhile,we found the expression of p53 and PCNA in mice bearing sarcoma 180 was affected in various groups.It suggested that compound anti tumor granules had antitumor effect and its possible mechanism might be associated with inhibition the expression of mutate p53 and PCNA.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2001年第11期835-836,F004,共3页
Medical Journal of Chinese People's Liberation Army
