摘要
本文报道了抗癌八号对动物实验性肿瘤及末梢血液中白细胞的影响。结果表明,ip及iv抗癌八号对小鼠S_(180)的肿瘤生长具有明显抑制作用(p<0.01),与环磷酰胺(Cy)相比,虽然作用稍弱,但iv抗癌八号不仅下降低白细胞,高剂量反有明显升高作用(p<0.01)。ip给药能明显延长艾氏腹水癌小鼠的存活天数(p<0.01),治愈率达41.7%,5-氟脲嘧啶组为33.3%。给药组小鼠体重皆有所增加。
The effects of No.8 drugs on experimental tumour and leucocyte count in peripheral blood stream were described. The results showed that both ip and iv of No.8 drugs inhibited the growth of S_(180)in mice significantly (p <0.01). Compared with cyclophosphamide, the effect of No.8 drugs was weeker.But iv of No.8 drugs not only did not decrease leucocyte count but its high dose increased leucocyte count significantly (p <0.01). Ip of the drugs can significantly prolonged the survival time of mice with Ehrlich Ascites Tumour(p <0.01), and the survival rate is 41.7%. The survival rate of 5-Fluorouracilum is 33.3%. All mice of given drugs'groups increased their weights.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1989年第6期348-350,共3页
Journal of China Pharmaceutical University
