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哮喘患儿诱导痰液中嗜酸性粒细胞阳离子蛋白测定 被引量:2

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摘要 目的  探讨诱导痰液中嗜酸性粒细胞阳离子蛋白 (ECP)测定在儿童哮喘中的应用价值。 方法  采用荧光酶标法测定 41例不同时期、不同程度的哮喘患儿和 11例正常儿童诱导痰液中ECP浓度 ,便携式肺功能仪测定肺通气功能。 结果  哮喘缓解组、轻度 -间歇组、中 -重度组诱导痰液中ECP含量〔(分别为 ( 4 8 7± 36 2 )、( 89 5± 5 7 6 )、( 15 2 7± 6 7 0 7) μg/L〕与对照组 ( 16 4± 2 2 2 ) μg/L比较有显著性差异 (P <0 0 5 )。不同程度哮喘患儿各组间诱导痰液中ECP含量有显著性差异 (P <0 0 1)。哮喘患儿诱导痰液中ECP含量与一秒钟用力呼气容积占预计值百分比 (FEV 1 0 % )呈显著负相关。 结论  诱导痰液中ECP含量可反映气道炎症的变化 。
出处 《小儿急救医学》 2001年第4期225-226,共2页 Pediatric Emergency Medicine
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