摘要
婴幼儿腹泻是儿童的常见病,A组轮状病毒(HRV)是本病的重要病原。根据中和试验已知,A组HRV至少有6个血清型,其中4个型能感染人。近年来,国内外都在研制HRV疫苗,以便有效地控制本病的流行。为此首先应弄清病毒的流行规律。本文报导应用单克隆抗体(McAb)ELISA法检定了长春、延边、大同、无锡和秦皇岛五地区1984～1987年秋冬季节婴幼儿腹泻轮状病毒的血清型。
Human rotaviruses(HRV)in infected stools collected from five regions (Changchun,Yanbian, Datong, Wuxi and Qinhuangdao)during the period 1984-1987 rotavirus seasons were tested for serotype by ELISA using monoclonal Vp7 antibodies and for electropherotype by PAGE. The results showed that serotype 1(79/151) and 2(54/151) strains were predominant in 4 regions in Northern China followed by serotype 3(15/151) and 4 (3/ 151) strains, whereas serotype 3 strain (9/12) seemed to be predominant in Wuxi region in Southern China. The predominant strains in the same region could switch from one serotype to another from year to year. Electro-pherotyping results on 140 HRV strains confirmed that HRV serotype 2 strains were of the short-pattern and serotype 1, 3 and 4 strains were of the long-pattern. These epidemiological data are useful for the design of rotavirus vaccine.
出处
《病毒学报》
CAS
CSCD
北大核心
1989年第4期393-397,共5页
Chinese Journal of Virology
关键词
婴幼儿
腹泻
轮状病毒
血清型
Infantile gastroenteritis Rotavirus Serotype
