摘要
采用乳化－冻凝技术制得顺铂白及微球。采用衍生化原理，使二乙基二硫代氨基甲酸钠（ＤＤＴＣ）与抗癌药顺铂（ＣＤＤＰ）反应，生成稳定的络合物Ｐｔ（ＤＤＴＣ）２，致紫外吸收度增加，并依据白及基质的光谱特点，用二阶导数法消除白及基质对含量测定的干扰，从而建立了药物含量测定方法。回收率９８．６０％，ＲＳＤ＝１．９６％。方法简便，对仪器要求低，易于开展，效果满意。
In this paper the principle of derivatization was employed.Cisplatin reacted directly with sodium diethyldithiocarbamate(DDTC) producing the Pt(DDTC) 2 complex, absorption of which increased greatly at 347nm.In view of the characteristic of spectrophotometric absorption of bletilla colloid, the second order derivative spectrophotometric method was established for determining Cis dichlorodiammine platinum(CDDP) in cisplatin bletilla striata microspheres(CBSM).The recovery was 98.60%,RSD 1.96%. The method is simple and rapid.
出处
《光谱实验室》
CAS
CSCD
1998年第6期62-65,共4页
Chinese Journal of Spectroscopy Laboratory
基金
国家自然科学基金
卫生部科研基金
关键词
肝靶向制剂
顺铂白
微球
衍生化法
含量测定
抗肿瘤药物
Hepatic Targeting, Cisplatin Bletilla Striata Microspheres,Derivatization,Content Determination.
