摘要
为了探讨急性淋巴细胞性白血病 (ALL)患者脑脊液中可溶性白介素 - 2受体 (SIL - 2R)、白介素 6(IL - 6)的表达及意义 ,采用双抗夹心ELISA法测定 3 0例ALL患者脑脊液 (CSF)中SIL - 2R ,IL - 6水平 ,并与 10名正常者进行对照 .结果 :ALL合并中枢神经系统白血病 (CNS -L)组较CNS -L已缓解及未合并CNS -L组二者水平显著升高 (P <0 0 1) ;CNS -L已缓解组二者水平接近对照组 (P >0 0 5 ) ;骨髓缓解及好转组二者水平低于治疗无效组 .结果表明 :监测二者水平变化有助于CNS -L早期诊断、估计预后、判断疗效 .
To evaluate the expression of solvable interleukin-2 receptor (sIL-2R) and interleukin-6 (IL-6) in cerebral spinal fluid (CSF) of patients with acute lymphocyte leukemia (ALL), the expressions of sIL-2R and IL-6 were measured by ELISA in CSF of 30 patients with ALL, compared with those from 10 normal controls. The levels of sIL-2R and IL-6 in all patients with central nervous systemic leukemia (CNSL) were significantly higher than those in patients with complete remissioned CNDL and without CNSL (P<0 01). The sIL-2R and IL-6 levels from patients with complete remissioned CNSL were similar to the normal controls (P>0 05). The sIL-2R and IL-6 levels in bone marrow CR or remitted ones were lower than those in failed treatment. In conclusion, the determination of sIL-2R and IL-6 was useful for the early diagnosis, the evaluation of efficacy and the prognosis of CNSL.
出处
《昆明医学院学报》
2001年第3期55-57,共3页
Journal of Kunming Medical College
