摘要
Y.Miyamoto等人根据小肠的生理和解剖特点,忽略小肠的固有运动对药物分布与吸收的影响,提出了肠内药物分布与吸收的二维层流、可渗壁多孔圆管模型。他们应用数值方法进行了计算。本文给出了包括灭活作用在内的上述模型的稳态解析解。所得结果与他们的数值解是一致的。解析解揭示了模型中各生理参数之间的相互关系,刻划了药物和营养物通过肠壁吸收规律,为在体实验测定肠壁对药物和营养物的渗透和反射系数提供了理论分析基础。同时从理论上证明了一些极为重要的结论。
According to the physiological and anatomical characteristics of small intes-tine, neglecting the effect of its motility on the distribution and absorption of drug, Miyamoto et al. proposed a model of two-dimensional laminar flow in a circular porous tube with permeable wall and they calculated the concentration profile of drug by numerical analysis. In this paper we gave a steady state analytical solution of above model including deactivation term. The obtained results were in agreement with the numerical results of Miyamoto et al., but the analytical solution revealed the relation among the physiological parameters of the model and described the absorption rule of drug and nutrient through the intestinal wall as well as provided theoretical basis for in situ experimental determination of permeability and reflection coefficients.
出处
《力学学报》
EI
CSCD
北大核心
1991年第1期37-45,共9页
Chinese Journal of Theoretical and Applied Mechanics
基金
山东省自然科学基金
关键词
小肠
药物
分布
吸收
模型
解析解
drug and nutriment, distribution and absorption in small intestine, model and analytical solution
