摘要
目的 系统性红斑狼疮 (SLE)的遗传流行病学研究表明 ,该病具有一定的遗传倾向性。方法 应用POINTER程序对 2 15例先证者及其核心家系进行复合分离分析 ,以探讨可能的遗传模式。结果 非传递模型被拒绝 ,接受多基因模型 (包括显性和隐性模型 )。结论 由于主基因模型和多因子模型被接受 ,提示本病可能是一种具有多主基因的多因子疾病。SLE不符合单基因遗传模式 ,应关注SLE亚型或表型与非MHC(non -MHC)的遗传易感性关系及其可能表现出的遗传模式。
Objective The genetic epidemiological studies on systemic lupus erythematosus(SLE) suggested that the disorder has some genetic component.Methods Complex segregation analysis was performed with their nuclear families through 215 Chinese probands using POINTERS software.Results The result presented that analysis of entire samples allowed rejection of no transmission model, and no rejection of polygenic model as well as major gene model(including dominant and recessive models).Conclusion SLE could be a multifactorial disease with Multi-Major-Locus.More attention to the subtypes or phenotypes and their genetic models of SLE should be paid in future.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2001年第6期492-494,共3页
Chinese Journal of Public Health
关键词
系统性红斑狼疮
复合分离分析
遗传模式
systemic lupus erythematosus
complex segregation analysis
genetic mode
