摘要
目的 :比较 4组以顺铂为主的联合化疗方案治疗NSCLC的近期疗效及毒副反应。方法 :分别用MVP(MMC、VDS、DDP)、IEP(IFO、VP 16、DDP)、TP(TAX、DDP)和NP(NVB、DDP)方案治疗晚期NSCLC139例。 2周期后评价疗效并记录不良反应。结果 :各组有效率分别是 :MVP36 6 % (15 / 4 1) :IEP37 9% (11/ 2 9) ;TP4 3 7% (14/ 32 ) ;NP4 3 2 % (16 / 37) ,各组均未见完全缓解病例。主要毒副反应是骨髓抑制、恶心、呕吐和脱发。结论 :以紫杉醇和异长春花碱分别与顺铂组成的TP和NP方案治疗晚期非小细胞肺癌 ,疗效稍高于既往的MVP和IEP方案 ,毒副作用相似。
Objective:To compare the recent efficacy and toxicity of four combined chemotherapy regiments containing cisplatin and others for advanced non small cell lung cancer(NSCLC).Methods:One hundrend and thirty nine patients with NSCLC were treated with ①mitomycin C plus vindesine plus cisplatin (MVP,41 cases),②ifosfamide plus etopside plus cisplatin (IEP,29 cases),③taxol plus cisplatin(TP,32 cases),and ④ novelbine plus cisplatin (NP,37 cases),respectively.Efficacy was evaluated and toxic reactions were recorded after 2 cycles,and all clinical data were analysed statistically.Results:The response rate was 33.6% in patients treated with MVP,37.9% with IEP,43.7% with TP,and 43.2% with NP,respectively.There were no completely remission in all patients.The major toxic reactions in the four groups were myelo suppression,vomit and alopecia,but all the toxicity were tolerable.Conclusion:TP and NP are better in treating advanced NSCLC than usually used MVP and IEP,and toxicity are similar.
出处
《山东医科大学学报》
2001年第4期313-315,共3页
Acta Academiae Medicinae Shandong
关键词
肺肿瘤
非小细胞肺癌
药物疗法
治疗
疗效
毒副反应
Lung neoplasms
cancer,non small cell lung
drug therapy,combine
side effect
