摘要
将人重组白细胞介素 -8(rh IL-8)动员的雄性小鼠外周血单个核细胞 (MNCs)静脉输注给受到 8.5Gy照射的同种雌性小鼠 ,并对存活的受体小鼠进行 Y染色体 PCR检测。结果表明 ,经 rh IL-8动员的造血干 /祖细胞可使受照射小鼠长期重建造血。提示 rh IL-8具有快速有效的动员造血细胞的作用。
The peripheral blood mononucleus cells(MNCs) mobilized by recombinant human interleukin 8 (rhIL 8) were transplanted from male mice to lethally irradiated(8.5 Gy) recipient female mice.The peripheral blood cells of the recipient female mice which were transplanted with MNCs obtained from rhIL 8 treated male donors were determined in using a Y chromosome specific probe(PCR analysis).In addition to their radioprotective capacity,the MNCs mobilized by rhIL 8 showed also long term repopulating ability to the lethally irradiated mice.It was proved that rhIL 8 had rapid and potent effect of mobilizing hematopoietic cells.
出处
《辐射防护通讯》
2001年第3期19-21,30,共4页
Radiation Protection Bulletin
基金
国防科工委"九五"国防预研资助项目 (57.3 .1 )
关键词
白细胞介素-8
放射损伤
动员剂
造血干细胞
治疗
造血细胞
Interleukin 8 BALB/c mouse Radiation injury Mobilization agent Hematopoietic stem/progenitor cells
