摘要
目的 研究rhIL 8对放射损伤小鼠的保护作用及其机理。方法 在小鼠受照前不同时间给予腹腔注射rhIL 810 μg或 30 μg ,观察动物的存活情况及一些指标。 结果 小鼠受照后的存活时间与rhIL 8的给药剂量及时间密切相关。通过检测受照后小鼠的骨髓细胞CUF GM计数、血清总SOD活性及MDA含量以及一些免疫功能指标 ,提示它们与动物的存活时间有内在联系。结论rhIL 8具有一定的抗放作用 ,其机理可能与造血调控、免疫调控、清除自由基等多方面有关。
Objective\ To study the radioprotective effects of rhIL\|8 on irradiated mice and its mechanism. Methods\ Single intraperitoneal injections of rhIL\|8 at 10 μg or 30 μg at different times to BALB/c mice before they were exposed to 8.5 Gy or 6.5 Gy 6 MV X\|rays.The survival state of mice and some monitoring indices were observed. Results\ The survival times of irradiated mice were closely related to the dose lever of rhIL\|8 and the injection time.CFU\|GM counts of bone marrow cells,serum total contents of superoxide dismutase (T\|SOD) and malondialdehyde (MDA),and immunity function indices were examined in all mice at six days after expousure 6.5 Gy 6 MV X\|rays.It is showed that the examination findings and the survival state of irradiated mice were interrelated with one another. Conclusion\ rhIL\|8 has certain radioprotective effects through complex mechanisms of modulation of hematopoiesis, immuno\|modulation,clearance of free radicals,etc.\;
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2001年第4期241-243,共3页
Chinese Journal of Radiological Medicine and Protection
