摘要
目的 :探讨内皮细胞型一氧化氮合成酶 (e NOS)与冰片促血脑屏障 (BBB)开放作用的关系。方法 :采用链菌素亲生物素 -过氧化氢酶法 (S- P法 )染色和抗 e NOS抗体的免疫组化方法 ,观察正常与脑外伤情况下服用冰片后大鼠脑微血管内皮细胞 (EC)中 e NOS表达量的变化。结果 :脑外伤时 ,因 EC受损 ,e NOS表达减弱 ,冰片可增加生理、病理状态下大鼠脑微血管内皮细胞中 e NOS的表达量。结论 :NO与冰片促
Objective: To observe the relationship between Nitric Oxide Synthase and the function of borneol in stimulating the BBB`s opening.Methods: The experimental brain injury was induced in the SD rats ( n =40) and the expression of eNOS in the rat brain microvascular endothelium was examined using multilcolonal antibody to eNOS by immunohistochemistry and S-P histochemistal methods.Results: When the brain was injured, EC were hurt, and then the eNOS expression diminished, borneol can strengthen the eNOS expression both in physiological and pahological conditions.Conclusion: NO has relationship with the function of borneol in stimulating BBB s opening, at somewhat extent.
出处
《脑与神经疾病杂志》
2001年第4期207-209,共3页
Journal of Brain and Nervous Diseases
关键词
冰片
血脑屏障
一氧化氮
一氧化氮合成酶
broneol boold-brain barrier nitric oxide nitric oxide synthase
