摘要
目的 :探讨心脉通胶囊对实验性大鼠急性心肌缺血的预防效果及与一氧化氮 (NO)的相关机制。方法 :应用垂体后叶素致大鼠急性心肌缺血模型 ,测定其心室肌组织一氧化氮合酶 (c NOS) m RNA的表达 ,结果用积分光密度 (IOD)表示。结果 :急性心肌缺血组大鼠心室肌组织 c NOS m RNA的表达为 2 0 .8± 4.1,明显低于正常对照组 5 6 .5± 12 .0 ,差异非常显著 (P<0 .0 1) ;心肌缺血前使用心脉通胶囊组的心室肌组织 c NOSm RNA的表达为 38.2± 8.0 ,高于急性心肌缺血组 (P<0 .0 5 ) ,但仍低于正常对照组 (P<0 .0 5 )。结论 :心脉通胶囊可能通过提高心室肌组织表达 c NOS m RNA,进而使 NO产生增加 ,达到改善心肌缺血的作用。
Objective:To study the prevent effects of Xinmaitong capsule(心脉通胶囊) against experimental myocardial ischemia of rats and mechanism associated with the production of nitric oxide(NO).Methods:Rat model of acute myocardial ischemia induced by pituitrin was used in this study,and the lift of ST segment in ECG was used as the index of myocardial ischemia.Constitutive nitric oxide synthase (cNOS)mRNA of ventricular wall in myocardial ischemia of rats were determined.Results:cNOS mRNA in ventricular wall of acute myocardial ischemia were 20.8±4.1,and markedly lower than control 56.5±12.0(P<0.01).After administration of Xinmaitong capsule,cNOS mRNA in ventricular wall of myocardial ischemia were elevated to 38.2±8.0(P<0.05).Conclusions:Xinmaitong capsule can elevate the expression of cNOS mRNA and content of NO,and exert the effect of improving myocardial ischemia in rats.
出处
《中国中西医结合急救杂志》
CAS
2001年第4期243-245,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
