摘要
目的 观察心痛宁对大鼠血小板聚集性及膜流动性的影响。方法 将Wistar大鼠随机分为心痛宁高剂量组 (15g kg 日生药 )及低剂量组 (7.5g kg 日生药 )、阿司匹林组 (5mg kg 日 )、未用药组及正常对照组 ,共灌胃七日。然后以皮下注射肾上腺素 (0 .9mg kg)加冰水刺激法造模 ,18小时后采血 ,以比浊法测血小板聚集率、荧光偏振法测血小板膜流动性。结果 心痛宁可抑制血小板聚集率的升高 ,防止血小板膜流动性下降 ,其作用与阿司匹林无显著性差异。
Objective:To observe the effetcs of Xin Tong Ning decoction on platelet aggregation and membrane fluidity in rats with blood stasis Zheng caused by cold-congelation.Methods:Acute myocardial ischemia model was established by epinephrine and ice water stress in rats.platelet aggregation rate was measured photometrically.membrane fluidity of platelet was measured by fluorescence polarization.Results:Xin Tong Ning decoction could suppress the increase of platelet aggregation and prevent platelet from decrease of membrane fluidity in rats with acute myocardial ischemia.The effects had no significant differences between Xin Tong Ning decoction and Aspirin.Conclusion:The effets of Xin Tong Ning decoction on platelet aggregation and membrane fluidity had important value in the prophylaxis and treatment for unstable angina pectoris or acute myocardial infarction.
出处
《中国血液流变学杂志》
CAS
2001年第2期102-104,共3页
Chinese Journal of Hemorheology
