摘要
目的:观察王清任三逐瘀汤(通窍活血汤、血府逐瘀汤和膈下逐瘀汤)对心肌缺血损伤的保护作用。方法:设假手术组、模型组(结扎家兔冠状动脉左前降支造成心肌缺血)及三逐瘀汤组共五组进行实验。结果:缺血3h后,心肌形态结构明显改变,表现为心肌出血、变性、灶性坏死、炎性细胞浸润;心肌细胞出现明显的水泡变性改变,细胞核固缩、染色质边聚,肌丝纤维呈带状凝聚,肌丝溶解,线粒体水肿空泡样变、嵴断裂消失、基质透亮;血清磷酸肌酸激酶(CPK)活性明显升高(P<005);心肌一氧化氮(NO)含量明显下降(P<005)。结论:三逐瘀汤对心肌缺血损伤均有不同程度的保护作用,其中尤以血府逐瘀汤和膈下逐瘀汤作用明显。
Objective: Observe protective effect of Wang Qing ren's three Stasis Expelling Decoctions(Orifice Freeing Blood quickening Decoction,House of Blood and Infradi Aphragmatic Stasis Expelling Decoctions)to ischemia of myocardium.Method:there are five groups including pseuoperative group(cause is chemia of myocardium by ligating coronary left front ramus),model group,three Stsis Expelling Decoctions groups in experiment.Result: Showed that morphological structure of myocardium changed obviously,including hemorrhage,denaturization and oven necrolysis,inflammatory cell soakage of myocardium after ischemia 3 hours.Myocardium cells appeared vacuole denaturization,and were found karyon pycnosising,chromatin side collecting,zonal coacervation of myofilament fibre,myofilament liquefier,oedematous vacuole denaturization of mitochondia,ridge collapsing and disappearing,stromatin changing transparently in them.Activity of serum creatine phosphokinase(CPK)increased( P <0 05) and quantum of NO in myocardium decreased apparently( P <0 05).Conclusion: Three decoctions have various degrees of effect to injury of ischemia of myocardium,especially effect of House of Blood and Infradi Aphragmatic Stasis Expelling Decoctions are remarkable.
出处
《中国中医基础医学杂志》
CAS
CSCD
2000年第2期37-41,共5页
JOURNAL OF BASIC CHINESE MEDICINE
关键词
膈下逐瘀汤
心肌缺血
王清任
保护作用
改变
血府逐瘀汤
损伤作用
变性
细胞核
染色质
Orifice Freeing Blood quickening Decoction
House of Blood Stasis Expelling
Decoctions
Infradi Aphragmatic
Stasis Expelling
Decoctions ischemia of myocardium
CPK
NO
