摘要
目的 探讨基底细胞癌 (BCC)Sexton病理亚型划分标准与其生物学行为的关系。方法 按该标准将 46例BCC划分为 6个亚型 ,并据此分为非侵袭性和侵袭性BCC组。采用免疫组化SP法检测Bcl- 2蛋白在石蜡切片上的表达 ,并进行图像分析以比较两组BCCBcl- 2蛋白的表达差异。结果 46例BCC中结节型、混合型和浸润型所占比例最高 ,分别为 39% ,2 8% ,1 7% ;非侵袭性BCC组 2 1例 ,侵袭性组 2 5例 ;前者Bcl- 2蛋白表达水平高于后者 ,P值为0 0 0 5。结论 对BCC作出病理亚型的诊断是必要的 ;Sexton病理亚型标准反映了BCC生物学行为的差异 ,采用该标准可区分非侵袭性和侵袭性BCC ,有利于治疗方法的选择。
Objective To explore the relationship between Sexton pathological subtype criteria and biological behavior of basal cell carcinomas(BCC). Methods 46 patients with BCC were divided into 6 pathological subtypes by Sexton pathological subtype criteria, or were divided into non-aggressive or aggressive groups. The expression of Bcl-2 protein was evaluated in formalin fixed,paraffin embedded tissue by immunohistochemical methods, and was analyzed by image-analysis. Results Nodular mixed and infiltrative subtype were the most common subtypes accounted for 39%, 28% and 17% respectively. Other subtypes were less common. There were 21 cases in non-aggressive group and 25 in aggressive group. The Bcl-2 protein expression was higher in non-aggressive group than in aggressive group, P value was 0 005. Conclusion It is necessary to classify subtype on diagnosis of BCC. Sexton pathological subtype criteria can reflect biological behavior of BCC and is helpful for distinguishing non-aggressive BCC from aggressive BCC. [
出处
《广东医学》
CAS
CSCD
2001年第8期673-674,共2页
Guangdong Medical Journal
