摘要
本文介绍了用放射免疫法测定的43和67名正常人、14例尿毒症和21例血液透析(血透)患者血清游离T_3(FT_3)、游离T_4(FT_4),总T_3(TT_3)、总T_4(TT_4)和促甲状腺素(TSH_(1RMA))水平,观察到虽然尿毒症和血透患者甲状腺功能正常,但是血清FT_3、FT_4和TT_3平均水平明显降低,TT_4和TSH_(1RMA)正常。FT_3、FT_4、TT_3和TT_4低于正常值的出现频率;在尿毒症组分别为35.7％,42.9％、50％和21％;在血透组分别为81％、38.1％、61.9％和14.2％。一次性透析后血清TSH_(1RMA)水平明显降低而血清FT_3、FT_4、TT_3和TT_4没有变化。维持性透析过程中未见血清甲状腺素水平变化。对上述变化进行了讨论,认为TSH_(1RMA)水平在尿毒症和血透患者中评定甲状腺功能状态是一个有用的指标。
Serum levels of free T3(FT3), free T4(FT4), total T3(TT3), total T4(TT4) and TSHIRMA were measured in 43 and 67 normal subjects and 14 uremic patients, and 21 patients receiving hemodialysis. Significantly lowered mean serum FT4 FT4 and TT3 but normal T4 and TSHIRMA were observed in uremic and hemodialysis ones, although all subjects were in the state of euthyroidism, The rates of low FT3, FT4, TT3 and TT4 were 37.5%, 42.9%, 50% and 21% in uremic patients and 81%, 38.1%, 61.9% and 14.2% in hemodialysis patients, respectively. The postdialysis TSHIRMA level was significantly reduced and FT3, FT4, TT3 and TT4 were unchanged after one hemodialysis. There was no change of the rates of low FT3, FT4 TT3 and TT4 in the course of repeated dialysis.The conclusion is that FT3, FT4, TT3 and TT4 are lowered in most uremic and hemodialysis patients while TSHIRMA is normal or only slightly lowered. The thyroid function of them is most likely normal (euthyroid). TSHIRMA is a useful index in diagnosing hypothyroidism in uremic and hemodialysis patients. Transient and maintained hemodialysis do not dramatically change the thyroid hormones and TSHIRMA levels.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1991年第2期117-120,共4页
Medical Journal of Chinese People's Liberation Army
