摘要
对１５例维持性血液透析（ＨＤ）患者进行了血小板聚集试验和部分凝血参数测定。结果显示，ＨＤ组血小板聚集率和血小板ＡＴＰ释放均显著低于正常对照组（Ｐ＜０．０１），表明ＨＤ患者存在血小板功能缺陷。血液透析后血小板聚集率和血浆血栓烷Ｂ２水平显著增高（Ｐ＜０．０１），提示血透过程中血小板被激活。凝血多数测定结果显示ＨＤ组血浆纤维蛋白原和ＶＷＦ水平显著高于对照组（Ｐ＜０．０５），而抗凝血酶Ⅲ活性和纤溶酶原活性则低于对照组（Ｐ＜０．０５）。作者初步讨论了这些变化的机理及其对止血凝血功能的影响，认为它们是引起ＨＤ患者出血倾向和血栓栓塞现象的重要原因。
latelet agsregation test
and somecoagulation parameters were measured in 15patients on maintenance hemodialysis
(HD).The results showed that platelet aggresation andreleasing ATP content from platelet of HD
groupwere significantly lower than that of controlgroup ( P< 0. 01). It suggested there
existeddysfunction of platelet in HD patients. Afterhemodialysis, platelet aggregation and
plasmathromboxane B2 were significantly enhanced ( P<0. 01 ). It was revealed that platelet
wasactivated during hemodialysis. Referring tocoagulation parameters, plasma fibrinogen
andvon Willebrand factor levels of HD group weresignificantly higher than that of control group
(P<0. 05 ) : while antithrombin-Ⅲ andplasminogen activities of HD group were lowerthan that of
control group ( P< 0. 05). Themechanism and the effect on hemostatic andcoagulative functions
of these chanses werediscussed preliminarily. It was eoncluded thatthese disturbances were
the important causes ofbleeding tendency and thromboembolic events inHD patients.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1994年第4期265-269,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
