摘要
目的：观察缺血性心力衰竭（心衰）患者血小板功能状态的变化。 方法：采用放射免疫法及流式细胞技术测定４５例缺血性心衰患者（心衰组）血浆凝血烷Ａ２（ＴＸＡ２）的代谢产物凝血烷Ｂ２（ＴＸＢ２）及前列环素（ＰＧＩ２）的代谢产物６－酮前列腺素１α（６－ｋｅｔｏＰＧＦ１α）、血小板膜糖蛋白ＣＤ６２Ｐ、ＣＤ６１（Ⅲａ）及血小板聚集率，并与４１例ＮＹＨＡ分级心功能正常的冠心病患者（对照组）进行对照。 结果：心衰组患者ＴＸＢ２的水平、ＣＤ６２Ｐ、ＣＤ６１及血小板聚集率均显著高于对照组（Ｐ均＜０．０１＝，６－ｋｅｔｏ－ＰＧＦ１α明显低于对照组（Ｐ＜０．０５＝。 结论：缺血性心衰患者血小板呈相对激活状态，有利于血小板的粘附、聚集及血栓前状态的形成。
Objective:To investigate the state of platelet function in patients with ischemic heart failure. Methods:Concentrations of thromboxane B2(TXB2),and 6-keto-PGF1α in plasma,an d platelet membrane glycoprotein CD62P,C D61(Ⅲa)were measured in 45 patients with ischemic heart failure and compared with those of 41 controls by ELISA and flow cytometric analysis respectively. Results:Plasma TXB2 level in and plat elet aggregating ratio were remarkably higher in patients with ischemic heart failure than in the control group(p<0.01= ,while plasma 6-keto-PGF lα level were rem arkably lower than in the control group( p<0.05=.Platelet membrane glycoprotein C D62P,CD61(Ⅲa)were significantly increased compared with those of the control gro up(p均<0.01=. Conclusion:Ischemic heart failure may be associated with platelet activation which,in turn,serves to promote platelet aggregation and prethrombosis.
出处
《中国循环杂志》
CSCD
北大核心
2001年第4期259-261,共3页
Chinese Circulation Journal
