摘要
目的观察乌司他丁对胃癌患者术后肝肾功能保护作用的临床疗效。方法选择同期行D2式胃癌根治性手术患者40例,随机分为治疗组(n=20)和对照组(n=20)。治疗组在术后1～3d每天予以生理盐水100ml加乌司他丁20万U静脉滴注,对照组仅给100ml生理盐水静脉滴注。同期检测治疗组和对照组手术前后血红蛋白、血清白蛋白、肝肾功能。结果治疗组术后第5天血红蛋白较术前明显升高(P<0.05),而对照组血红蛋白无明显改变;治疗组白蛋白仅在术后1d显著下降(P<0.01),术后3、5d与术前无明显差异,对照组术后1、3、5d白蛋白较术前显著下降(P<0.01);两组术后血清ALT水平较术前均有所升高但无统计学意义,但治疗组升高的幅度均小于对照组,治疗组TBIL水平术后第一天明显上升(P<0.01),随后即下降与术前无差异,对照组TBIL水平无明显改变;治疗组术后1～3d血清Cr水平明显下降与术前相比差异有统计学意义(P<0.01),而BUN较术后无明显下降,差异无统计学意义(P>0.05);对照组术后血清Cr、BUN水平较术前明显升高(P<0.01),但与治疗组同期相比差异无统计学意义(P>0.05)。结论乌司他丁可以明显改善胃癌患者的蛋白质代谢异常并对患者的肝肾功能有一定的保护作用。
Objective To observe and analyze the Ulinastatin‘s protective effects on postop- erative liver and renal function of the patients with gastric cancer. Methods Forty patients with gastric cancer accepting D2 radical surgery during the same period were selected and randomly divided into 2 groups：treatment group and control group. In treatment group, the patients were subjected to the intravenous drip of normal saline （ 100 ml） plus Ulinastatin （2.0 ×105 U） per day on the postoperative day 1～3, and those in control group only to normal saline （ 100 ml）. Hemoglobin ,serum albumin and the liver and renal function pre - and post - operation were determined and compared in the two groups. Results The hemoglobin in treatment group was increased obviously on 5th day postoperation （P 〈 0.05）, and that in control group had little change. The albumin was just dropped largely on 1st day postoperation in treatment group （P 〈0.01 ） ,then had nothing different on 3rd and 5th day after operation. However,the situation was just opposite in the control group. Both of the levels of ALl＇ were slightly increased but had no statistically significant,and the elevated extent in treatment group was smaller than that one. The TBIL in treatment group was increased obviously as compared to that before operation on the first day postoperation （P 〈 0. 01 ）, and descended subsequently, but there was no change in the control group. In treatment group ,the level of Cr was decreased largely on 1st ,3rd ,5th day after the operation （P 〈0.01 ）, but BUN was not obviously decreased （ P 〉 0.05 ）. In control group, both Cr and BUN were increased obviously after operation （P 〈 0.01 ）. Conclusion Ulinastatin can improve the abnormal metabolism of the protein in the patients with gastric cancer and also can play certain role in protecting the function of liver and kidney.
出处
《临床外科杂志》
2008年第4期250-252,共3页
Journal of Clinical Surgery
关键词
乌司他丁
胃癌
肝功能
肾功能
Ulinastatin
gastric cancer
liver function
renal function
