摘要
目的 探讨可能影响α 干扰素 (IFN α)中和抗体 (NA)产生的有关因素。方法 采用抗病毒中和生物测定法 (ANB)检测 1 1 6例IFN α治疗的慢性病毒性肝炎患者血清中的NA。结果 IFN α治疗前ALT(基础ALT)高水平组NA阳性率明显低于基础ALT低水平组 (P <0 .0 5) ,病毒阴转率则高于后者 (P <0 .0 5)。而乙型肝炎与丙型肝炎、男性与女性、年龄高低三者各NA阳性率也分别有所不同 ,但均无统计学差异 (P >0 .0 5)。结论 NA的产生与患者感染病毒类型 (乙或丙肝病毒 )、性别差异及年龄高低无明显关系 ,但与基础ALT水平的高低有关。基础ALT高水平者NA产生率较低 ,IFN疗效较好。此有助于IFN治疗的临床病例选择。
Objective To investigate the factors which might influence the neutralizing antibody(NA) development in patients treated with interferon α(IFN α). Methods 116 patients with chronic viral hepatitis treated with IFN a were studied, the NA in their sera were tested by using the antiviral neutralizing bioarray(ANB).Results The incidence of NA were 8.9%(5/56) in the group with high level ALT(ALT≥80IU/L), and 25%(15/60) in the groups with low level ALT (ALT<80IU/L).There was significant difference between two groups(P<0.05).But there were no statistically differences between NA positive and NA negative patients with respects to the type of hepatitis virus ,sex and age (P>0.05).Conclusion The incidence of NA is related with the level of baseline ALT in patients.The frequency of NA development are no related with respects to the type of virus ,sex and age ,exception for the level of baseline ALT. So the latter is helpful for choosing cases for IFN α treatment in clinics.
出处
《临床内科杂志》
CAS
北大核心
2001年第5期363-365,共3页
Journal of Clinical Internal Medicine
