摘要
为了探讨α干扰素（ＩＦＮα）中和抗体（ＮＡ）在病毒性肝炎患者中的发生率及其时间变化规律性，采用抗病毒中和生物测定法（ＡＮＢ）检测了３２例健康人和１１６例ＩＦＮα治疗的慢性病毒性肝炎患者血清中的ＮＡ。结果健康人及ＩＦＮ治疗前患者血清中未检出ＮＡ，而ＩＦＮ治疗后患者共有２０例ＮＡ阳性，总检出率为１７．２％。其中ＩＦＮα２ａ、ＩＦＮα２ｂ、ＩＦＮα１ｂ治疗组ＮＡ阳性率分别为３４．６％、１３．２％和１１．５％。ＮＡ出现的时间变化随治疗时间的增加，阳性率逐渐递增。提示病毒性肝炎患者ＩＦＮα治疗后可产生ＮＡ，且具有一定的时间规律性。不同亚型的ＩＦＮα治疗后ＮＡ发生率不同。
To understand the regularity of neutralizing antidbody(NA)development.32 healthy person and 116 patients with chronic viral hepatitis treated with interferon-alpha(IFN )were studied,and the NA in their sera were tested by using the antiviral neutralizing bioassay(ANB).The results showed that none was positive for NA in sera from the health persons and patients before IFN treatment,the incidence of NA in patients after IFN2 therapy was 172%(20/16).Of the 26 patients treated with IFN 2a,346% developed NA,whereas NA were detected in 132% of 38 and 115% of 52 patients treated with IFN 2b and IFN 1b,respectively.NA appeared regularly in 20 NA positive patients.They(20)were positive after 6 months,The development of NA has its regularity in patients with viral hepatitis treated with IFN .The frequencies of NA development are related with the subtypes of IFN used.
出处
《临床肝胆病杂志》
CAS
北大核心
1999年第1期34-40,共7页
Journal of Clinical Hepatology
关键词
Α-干扰素
中和抗体
病毒性肝炎
NA
Interferon
Neutralizing Antibody
Viral Hepatitis
Antiviral Neutralizing Bioassay
