摘要
目的探讨非洛地平（ＦＭ）与苯那普利（ＢＥ）对高血压病患者胰岛素抵抗（ＩＲ）及代谢的影响。方法测定１２２例高血压患者和３８例正常血压作对照组（ＮＳ）的胰岛素敏感性指数（ＩＳＩ）及血脂等水平，根据ＩＳＩ值，把高血压分为高血压Ⅰ组（６８例）与高血压醇Ⅱ组（５４例），再分别把高血压Ｉ组和高血压Ⅱ组各随机分为非洛地平（ＦＭ）组与苯那普利（Ｂ）组，治疗８周后再测定ＩＳＩ及血脂等变化。结果（１）Ⅰ组的ＩＳＩ明显低于 Ⅱ组及阳组（Ｐ＜０．０５），而 Ⅱ组的ＩＳＩ与ＮＳ组之间差异无显著意义（Ｐ＞０．０５）；（２）两药治疗后血压均较治疗前显著降低（Ｐ＜０．０１）；（３）Ⅰ组经两药治疗后ＩＳＩ值均明显升高（Ｐ＜０．０１），Ⅱ组经两药治疗后ＩＳＩ无显著变化（Ｐ＞０．０５（４）两药治疗后，Ⅰ组各项代谢指标均无显著变化（Ｐ＞０．０５）。结论ＦＭ与ＢＥ均可明显改善高血压Ⅰ组患者的ＩＲ，两药短期治疗对其它代谢指标无影响。
Objective To evaluate the effect of felodipine( FM) and benazeprie( BE) on insulin resistance( IR) and metabolism in hypertensive patients. Methods 122 patients with hypertension and 38 patients with normal blood pressure that insulin sensitive index(ISI) and the level of serum lipids were measured. Depend on value of ISI , hypertensive patients were divided into the I group of metabolism hypertension( MH) with 68 persons and the II group of common hypertension( CH) with 54 persons. The group of MH and CH were divided into the FM and BE group in random. After 8 weeks treatment,the ISI and serum lipids were measured again. Results 1. The ISI of group MH was remarkable lower than that of group CH and NS( P < 0.05) ,but the 151 value between Group CH and Group NS had no significance. 2. After the treatment of FM and BE ,the blood pressure was significantly lower (P<0.01). 3. With whatever the treatment ofFM or BE,the 151 of Group MH were all remarkable higher(P< 0.01) ,while the 151 of Group CH had no significantly change( P>0.05). 4.With whatever the treatment ofFM or BE, all metabolism indexes of Group MH had no significantly change(P >0.05). Conclusion Both FM and BE could significantly ameliorate the IR of patients with metabolism hypertension ,and the short-term treatment with FM or BE would not effect on the other metabolism indexs.
出处
《贵州医药》
CAS
2001年第9期789-791,共3页
Guizhou Medical Journal
