摘要
目的:探讨伊贝沙坦对高血压病患者内皮功能及胰岛素抵抗的影响。方法:48例原发性高血压患者口服伊贝沙坦1 2周,治疗前、后采静脉血测定空腹及餐后2 h血糖、胰岛素、C肽,并计算各自胰岛素敏感指数,同时用高分辨率血管外超声法检测肱动脉内皮依赖性血管舒张功能。结果:伊贝沙坦治疗1 2周后患者的收缩压和舒张压均降低;空腹、餐后胰岛素及C肽水平较前降低;空腹、餐后胰岛素敏感指数均较前显著升高;肱动脉内径的基础值及血流介导的内皮依赖性舒张功能明显改善。
Objective: To investigate the effects of Irbesartan on endothelial function and insulin resistance in essential hypertension patients. Methods: The concentration of fasting blood glucose, 2-hour postprandial blood glucose, serum insulin and C peptide were measured in 48 patients with hypertension after 12 weeks treatment with Irbesartan. Endothelial function was assessed in the brachial artery by high-resolution ultrasound technique before and after the treatment. Results: After 12 weeks treatment with Irbesartan SBP and DBP was decreased. Fast insulin, 2-hour postprandial insulin and C peptide were reduced and insulin sensitive index was significantly increased. Basic diameter and flow mediated dilatation of brachial artery were improved. Conclusion: Irbesartan can effectively decrease blood pressure and improve endothelium-dependent vasodilation in brachial artery and insulin resistance.
出处
《陕西医学杂志》
CAS
北大核心
2005年第4期440-442,共3页
Shaanxi Medical Journal
