摘要
目的 检测治疗前鼻咽癌活检中癌细胞的有丝分裂指数和凋亡指数 ,探讨它们对肿瘤生长的影响。方法 收集治疗前鼻咽癌活检 43例。在HE切片上检测癌细胞的有丝分裂指数 (MI)。在末端标记细胞死亡检测 (TUNEL)染色片上计量凋亡指数 (AI)。结果 各例的MI和AI差异甚大 ,两个指数之间无相关性。根据这两个指数是高于和 /或低于均数 ,构成了反映肿瘤生长的四种可能性组合。MI>均数和AI<均数组的肿瘤生长较MI <均数和AI >均数组显著快。结论 治疗前各例鼻咽癌的生长快慢很不一样。在鼻咽癌生长进展过程中 ,存在着引起癌细胞有丝分裂和导致癌细胞凋亡两种事件 ;
Objective To quantitate the mitotic and apoptotic indices o f neoplastic cells in pretreated nasopharyngeal carcinoma(NPC) biopsies, and to i nvestigate their effects on tumour growth. Methods 43 pretreate d NPC biopsies were investigated. Mitotic index (MI) was evaluated on HE stained slides. Apoptotic index (AI) was quantitated on TUNEL (TdT-mediated dUTP-X Ni ck End Labeling)slides. Results Either MI or AI was varied greatly from case to case, and there was no correlation between these two indices. Basi ng upon the MI and AI being higher and/or lower than their respective means, the re were four possible combinations reflecting tumour growth. The tumor growth of the groups with MI>mean and AI<mean was significanltly faster than that with MI<mean and AI>mean. Conclusion The tumour growth rate of pre treated NPCs was varied greatly form case to case. In the course of NPC progress ion, two events are present,namely one that induces mitosis and another that cau ses apoptosis;however,the factors that influence mitosis play dominant role
出处
《肿瘤》
CAS
CSCD
北大核心
2001年第4期257-259,共3页
Tumor
基金
国家自然科学基金重点项目 (No .3 973 0 2 0 0 Ⅱ )
关键词
鼻咽肿瘤
有丝分裂
凋亡
Nasopharyngeal neoplasms
Mitosis
Apopto sis
